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Osteomyelitis can happen if a bacterial or fungal infection enters the bone tissue from the bloodstream, due to injury or surgery. Most often the bacteria are staphylococcus, but in sickle-cell children, both salmonella and staphylococcus are implicated. The bacteria are haematogenously disseminated and deposited in the trabecular bone or marrow, usually in the metaphysis of the proximal tibia or distal femur. Oteomyelitis manifests in patients with sickle cell anaemia when there is infections thorough some bacteria and could affect the bones with attendants effect in the activity of bone marrow which will affect the solid phase of blood and the quality of lives of the sickle cell anaemia patients. Preventive measures such personal hygiene should be adopted to avoid the danger such inflammation could cause in the patients.